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J Anat. Soskic V. Groebe K. Schrattenholz A. Nonenzymatic posttranslational protein modifications in ageing. Stadtman ER. Protein modification in aging. Additionally, it also causes free radical formation, resulting in oxidative stress. Whereas ultraviolet light and ionizing radiation both induce DNA lesions which trigger an activation of the p53 pathway, the magnitude of the p53 response elicited by ionizing radiation is comparatively low.
Ultraviolet light-induced free radical formation in skin: an electron paramagnetic resonance study. Enhancement of nitrogen dioxide-induced lipid peroxidation and DNA strand breaking by cysteine and glutathione. UV induces oxy-and chromanoxyl free radicals in microsomes by a new photosensitive organic hydroperoxide, N,N-bis 2-hydroperoxymethoxyethyl -1,4,5,8-naphtalene-tetra-carboxylic-diimide. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?.
UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy.
Induction of the kD heat shock protein in organ-cultured normal human skin. Mechanism of lipid radical formation following exposure of epidermal homogenate to ultraviolet light.
Post-translational regulation of the 54k cellular tumor antigen in normal and transformed cells. Comparison of initial yields of DNA-to-protein crosslinks and single-strand breaks induced in cultured human cells by far-and near-ultraviolet light, blue light and X-rays.
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. GATAAG; a cis -control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells a review. Molecular and biochemical reprogramming of oncogenesis through the activity of prooxidants and antioxidants.
Identification of a novel p53 promotor element involved in genotoxic stress-inducible p53 gene expression. Augmented expression of HSP72 protein in normal human fibroblasts irradiated with ultraviolet light. Monoclonal antibody analysis of p53 expression in normal and transformed cells.
Yonish Rouach. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin This content is only available via PDF. Email alerts Article activity alert. Accepted manuscripts alert. Curr Biol — Hunter T Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.
Role in cell survival following oxidant injury. Curr Opin Cell Biol — Int J Biochem Cell Biol — Nature — Toth A, Jeffers JR, Nickson P et al Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion.
Biochem Biophys Res Commun — Download references. Long and The Molecular Cardiology Foundation. Xilin Long, Michael J. You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Long, X. Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes.
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